Quick dating
Custom Menu
  • interracial dating community
  • international dating inc
  • NEWS
    Some things you can do are, chat in groups using chat rooms, create your own free chat rooms, share your precious photos, make friends, build your friends list, message people with wap chat messenger PM, chat with smileys and so much more. strives to give users the best user experience possible, so we therefore keep active, and in touch with the mobile chat community!

    Peptidylglycine alpha amidating enzyme

    It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins. / Processing section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation.

    Once cleaved, a propeptide generally has no independent biological function.

    PHM share protein sequence similarity with dopamine-beta-monooxygenases (DBH), a class of ascorbate-dependent enzymes that requires copper as a cofactor and uses ascorbate as an electron donor.

    PHM and DBH share a few regions of sequence similarity, some of which contain clusters of conserved histidine residues that may be involved in copper binding [PMID: 11028916, PMID: 16301310].

    Conclusion: PAM-dependent amidation has the potential to signal oxygen levels in the same range as the hypoxia-inducible factor (HIF) system.

    Significance: Physiological effects of hypoxia may be PAM-dependent.

    Background: Peptidylglycine alpha-Amidating Monooxygenase (PAM) is solely responsible for catalysis of amidation, a biologically important post-translational modification.

    The Drosophila genome predicts expression of one monofunctional PHM gene and two monofunctional PAL genes [PMID: 15198673].

    It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first. This subsection of the “Names and Taxonomy” section is present for entries that are part of a proteome, i.e.

    of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced. This subsection of the ‘Subcellular location’ section describes the extent of a membrane-spanning region of the protein.

    The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part.

    C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

    Leave a Reply

    Pages: [1] 2 3 4 5 6 | Next | Last


    Copyright © 2017 - veme.alsinfo.ru